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Furosemide is a loop diuretic causing fast and short diuresis. It possesses natriuretic effect and also decreases levels of Cl- in blood, increases excretion of K+, Ca2+, Mg2+. Penetrating into a renal tubule in ascending thick limb of Henle's loop it blocks re-absorption of Na+ and Cl-. Due to increased excretion of Na+ secondary intensified excretion of water occurs and as well as increased secretion of K+ in distal part of the renal tubule. Simultaneously excretion of Ca2+ and Mg2+ increases. Furosemide is used to treat edema syndrome in patients with chronic heart failure (degree II and III), cirrhosis, diseases of kidneys, acute heart failure (pulmonary edema), brain edema, hypertensive crisis, arterial hypertension and others.

Dosage and direction

Diuretic lasix contains furosemide as active ingredient, therefore it is also known as lasix-furosemide. It has diuretic action due to the blocking re-absorbtion potassium and chlor ions in the ascending part of Henle’s loop. Lasix drugs also have some impact on convoluted tubules, however this mechanism has no connection to antialdosterone activity or suppression of carbonic anhydrase. What is Lasix used for? As usual this diuretic is needed to stabilize urine flow and to improve excretion of potassium, magnesium, and calcium.

Intravenouse Lasix can lower blood pressure quite fast and effective along with reducing pressure in the pulmonary artery, preloading and pressure in the left heart chamber. Diuretic effect of furosemide Lasix maybe seen already in just five minutes reaching its peak efficacy in just half an hour, meanwhile duration of diuretic period lasts two hours. Peroral use of Lasix medication starts within first hour reaching its peak in about one and half or two hours as maximum; the duration of effective period lasts not less than seven hours. It is known that Lasix drug is metabolized in the organism and then is excreted with urine flow as combination with glucuronic acid.

Swelling syndrome as a result of heart problems, kidney problems, liver problems, acute left heart chamber failure, burn disease, preeclampsia; forced diuresis; complex therapy for treating high blood pressure.

Lasix mechanism of action and Lasix dosage

Usage and dosage of Lasix without prescription is not recommended simply because it is should be established individual due to the dependence of water-electrolytes impairment and value of glomerular filtration. Later on the correction of dosage is always needed depending on patient’s condition and diuresis’ value. Usually Lasix medication is prescribed as Lasix pills, and note that it could be Lasix generics but in case if peroral use is impossible, then doctors may use IV Lasix (intravenous administration) by stream infusion, and the time of Lasix administration should not be less than 1.5-2.0 minutes.

Lasix for swelling

For the moderate intensity of edema syndrome initial Lasix dosage should be 20-80 mg peroral, or 20-40 mg intravenously or intramuscularly. If the effect is not good enough then the Lasix doses could be increased with another 40 mg peroral, or 20 mg intravenously. Increasing dosage is not allowed earlier than six-eight hours after the initial dose of Lasix oral . and not earlier than two hours after parenteral administration. Dosage correction should be done to reach adequate diuresis. Hence such experimentally gotten dosage can be prescribed once or twice a day. The maximum effect of this diuretic can be observed with taking the drug two-four times a week.

Lasix pediatric dose depends on the child’s weight and the way the Lasix is going to be administrated. Initial peroral dose is 2mg/kg, parenteral dose is 1 mg/kg. It is possible to increase the dose later on 2 mg/kg for peroral use in six-eight hours after initial Lasix dose and on 1 mg/kg with parenteral use in two hours after initial dose. Otherwise it will be too much Lasix that can lead to a development of complications.

Lasix diuretic for complex treating hypertension usually is 80 mg a day, but it is recommended to divided it into two equal dose. It is not recommended to increases the normal dose of Lasix due to the possible side effects of Lasix, in such cases doctors advice to add other antihypertensive medications.

In case of lungs edema Lasix should be administered by stream infusion (40 mg), if effect is not enough it is possible to add another 20-40 mg of intravenous Lasix in 20 minutes. For the forced diuresis 20-40 mg of Lasix should be added to a solution for the intravenous infusion. Later on the dose of Lasix may be corrected depending on water-electrolytes balance and patient’s condition.

Lasix side effects

The use of big doses of Lasix leads to the decrease of circulating blood volume which in turn leads to the blood thickening, therefore the development of blood clots is possible, and this is quite serious Lasix adverse reactions . One of the most common side effects is development of water-electrolytes impairment which is known as Lasix and metabolic alkolosis especially in presence of diabetes; deficit of sodium, chlor, calcium, potassium; impairment of biochemical characteristics of blood, including increased level of creatinine, cholesterol, triglycerides, uric acid (with acute gout), glucose (especially in presence of diabetes).

There are also a number of possible allergic reactions for different uses of Lasix including so called Lasix rash, dermatitis, itchiness, purpura, and erythema. It even could be anaphylactic shock. Blood problems are not common as lasix side effects but still can present in form of leukopenia, eosinophilia, hematolitic changes, agranulocytosis, thrombocytopenia. Preterm born babies and infants with low birth weight Lasix use during first weeks of life may lead to a patent ductus arteriosus.

Furosemide contradictions include any obvious impairment of water-electrolytes balance, intolerance of furosemide or any other component of Lasix drug . anuria, dehydration, deficit of circulating blood volume, any stage of liver coma, preganncy before twelve weeks and breastfeeding. Moreover, Lasix prescription during pregnancy after its twelve weeks should be done only in case of strong indications because this diuretic is able to go through placenta barrier.

Lasix interaction with other medications

It is known that Lasix may lead to the development of hypopotassaemia, which in turn leads to the enforcement of cardiac glicosides action. Combined therapy of Lasix and glucocorticosteroids and purgative medications needs a control of electrolytic blood composition, because such combined therapy increases risk of hypokalaemia. Lasix combination with cephalosporin range antibiotics or aminiglicosides may lead to the increase of their levels and thus to a stronger side effects of Lasix itsef. It is worth to remember that NSAIDs, probenicide, and phenytoin vam lessen the diuretic effect of Lasix. Diabetic drugs taken together with Lasix should be corrected properly. Lasix can enforce the toxic effects of theophyllin, lithium medications, and neuromuscular relaxants.

In case of Lasix overdose t he most common sign is hypotension, electrolytes balance impairment, dizziness, dry mouth, blur vision. To treat Lasix overdose one needs to restore the normal water-electrolytes balance and to stabilize the circulating blood volume.

Lasix is manufactured in the form of tablets: Lasix 40 mg (45 pills in a pack) and Lasix 40 mg (50 pills in a pack); and as a solution for intravenous administration (10 mg to 1 ml), each ampule contains 2 ml of Lasix iv . the pack has ten ampules.

How to store lasix at home?

Just put Lasix prescribed by doctor in a safe place without direct sunlight with romm temperature of 17-26 degrees centigrade.

Take exactly as it was prescribed by your doctor.

Precautions

Before using Furosemide, consult your doctor if you suffer from kidney disease, liver disease, gout, lupus, diabetes, or an allergy to sulfa drugs. Avoid becoming dehydrated as Furosemide makes you urinate more often. Do not stop taking the drug even if you feel fine as high blood pressure often has no symptoms. Avoid taking the drug if you are pregnant or breastfeeding.

Contraindications

Hypersensitivity, acute kidney failure with anuria, severe liver failure, liver coma and precoma, stenois of urethra, acute glomerulonephritis, urinary tract obstruction, precoma, hyperglycemic coma, gout, arterial hypotension, heart attack, pancreatitis and others.

Possible side effect

Contact your physician for medical attention if you have signs of allergy or any following conditions: dry mouth, thirst, nausea, vomiting; weakness, drowsiness, restless, or light-headed, fast or uneven heartbeat, muscle pain, less than usual urination or absence of urination, easy bruising or bleeding, red blistering skin rash, hair loss.

Drug interaction

Hearing damage may occur if Furosemide is administered with aminoglycoside antibiotics (gentamicin and others) or Edecrin - another diuretic. Concomitant use of Furosemide and aspirin may cause high blood levels of aspirin and aspirin toxicity. Furosemide is able to reduce excretion of lithium by the kidneys. Sucralfate (Carafate) reduces the action of Furosemide. Intake of Ingestion of Furosemide and Sucralfate should be separated by two hours.

Missed dose

The medication is sometimes administered for single use so you will not need a dosing schedule. If you take Furosemide regularly and forgot to take a dose take it as soon as you remember. Skip the missed dose if it is almost time for the next intake. Resume your regular schedule. Do not compensate the missed dose by taking an extra one.

In case of loss of appetite, ringing in ears, severe weakness, dizziness, confusion, lightheadedness, or fainting, seek for immediate doctor's attention.

Keep away from children at room temperature in a dry and dark place.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.Lasix (Furosemide) is a diuretic medication used to reduce fluid retention and swelling as a result of conditions such as heart failure, cirrhosis, chronic kidney failure, and nephrotic syndrome. Lasix (Furosemide) works by blocking the absorption of salt and fluid in the kidney tubules, causing a large increase in urine output.

Dosage and Administration

Typically you will be prescribed between 20mg and 80mg of Lasix (Furosemide) per day. However, as the reduction in fluid occurs your physician may recommend a change of dosage regime. You should only use Lasix as directed by your physician.

Side effects

With the increase in urine output some of the more common side effects reported after taking Lasix (Furosemide) include low blood pressure, and water and electrolyte depletion. Less common side effects include jaundice, ringing in ears (tinnitus), light sensitivity, rash, pancreatitis, nausea, abdominal pain, dizziness, anemia, and other blood disorders.

Precautions

Lasix (Furosemide) should be avoided by patients with kidney failure. The sudden loss of fluid and electrolytes can cause deterioration in kidney function that may result in the patient going into a coma.

Similarly, this medicine may also cause reduced levels of potassium and magnesium in the blood. The reduced levels may go on to contribute heart rhythm problems.

It is also known that the active ingredient in this drug reduces the kidney`s ability to excrete lithium. The continued failure to excrete lithium can result in lithium toxicity.

Lasix (Furosemide)

Brand Name: Lasix

Generic Name: Furosemide

You can buy Lasix online and without prescription.

Uses and Indications

Lasix is a loop diuretic (water pill) that prevents your body from absorbing too much salt, allowing the salt to instead be passed in your urine.

Lasix treats fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome. This medication is also used to treat high blood pressure (hypertension).

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Like other loop diuretics, Lasix acts by inhibiting the Na-K-2Cl symporter in the thick ascending limb of the loop of Henle. The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also abolishes the corticomedullary osmotic gradient and blocks negative as well as positive free water clearance. Due to the large NaCl absorptive capacity of the Loop of Henle, diuresis is not limited by development of acidosis, as it is with the carbonic anhydrase inhibitors.

Safe usage and general guidance

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Lasix will make you urinate more often and you may get dehydrated easily. Follow your doctor's instructions about using potassium supplements or getting enough salt and potassium in your diet.

If you are being treated for high blood pressure, keep using Lasix even if you feel fine. High blood pressure often has no symptoms.

Store Lasix at room temperature away from heat, light, and moisture. Lasix liquid medicine should be used within 60 to 90 days after opening the bottle. Ask your pharmacist how many days your medicine is good for. Throw away any unused liquid after that time has passed.

Precautions and risks

Before you buy Lasix, tell your doctor if you have kidney disease, liver disease, gout, lupus, diabetes, or an allergy to sulfa drugs. Avoid becoming dehydrated. Follow your doctor's instructions about the type and amount of liquids you should drink while you are taking this medication.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Lasix can make your skin more sensitive to sunlight and sunburn may result.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing.